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Amusingly, in Unfinished Tales of Nmenor and Middle-earth , the scene where Saruman berates Gandalf's smoking indicates that Saruman the Wise couldn't figure out the function or purpose of smoking without being explained

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Nicotine counters that effort through at least two distinct mechanisms simultaneously: direct NLRP3 activation and endothelial-driven oxidative stress

European governments continue to raise tobacco taxes to discourage consumption, while funding their healthcare systems

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