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Beyond direct regulation of neuronal excitability via synaptic plasticity, PICs can also enhance neuronal excitability by activating glial cells and promoting A1 (astrocytic) or M1 (microglial) polarization, leading to further release of pro-inflammatory cytokines

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Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway