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It also increased 4-hydroxynonenal levels and decreased GPX4 levels, which led to ferroptosis

Notably, IL-6 not only modulates hepcidin to affect the release of stored iron from ATMs and intestinal absorption, but also reduces transferrin expression and aggravates iron accumulation by promoting hepcidin production

10.1016/j.fct.2020.111240 40 JiaY.ChenK.LinP.LieberG.NishiM.YanR.et al (2014)

Organic acid complexation, heavy metal distribution and the effect of ATPase inhibition in hairy roots of hyperaccumulator plant species

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