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Emerging delivery vehiclesLNPs, AAVs, aptamer-guided carriers and stimulus-responsive nanoparticlesachieve modest extrahepatic exposure, typically under about 15% in muscle or adipose tissue, and contend with barriers imposed by the extracellular matrix and capillary endothelium

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Adv Sci 9:e2202679 Huang C, Guo Y, Li T et al (2024) Pharmacological activation of GPX4 ameliorates doxorubicin-induced cardiomyopathy

In fact, studies have indicated that as the number of depressive episodes increases in adults, neuronal degeneration increases

We acknowledge a possibility that the elusive high-affinity kinetically stabilising site could be located at the flexible interface between the regulatory domains and hence difficult to be resolved in cryo-EM studies