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CD47/signal regulatory protein alpha) to convert a cold TME into an inflamed, effector-permissive state [18]

NAFLD appears to be more frequent in industrialized countries, its global prevalence is about 25% and varies across different geographical areas, being higher in Middle East and South America and lower in Africa (33)

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Separately, serum Se was found to be lower in obese women, and hypermethylation of CPT1B, involved in lipid oxidation, suggested a potential link between Se levels and obesity [100]