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3 Metabolic comorbidities Diabetes is a well-known comorbidity in vitiligo ( However, epidemiological and genetic proof of a significant correlation between diabetes and vitiligo is not restricted to type 1 but also involves type 2 diabetes ( There is growing evidence that individuals affected by vitiligo may have an increased prevalence of metabolic syndrome, which is a cluster of conditions including insulin resistance, dyslipidemia, obesity, and hypertension (Tanacan and Atakan, 2020

79 Therefore, targeting the microbial tryptophan metabolism-AhR axis by supplementing specific probiotics (such as IPA-producing bacteria) or their beneficial metabolites is a potential strategy for regulating hepatic inflammation and metabolic disorders

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By the time we reach our late 20s, natural production often begins to decline, which is why many people start to feel the "slow down" of early middle age