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After further consideration of comments received in response to the initial guidance and of the process through which a claim is determined to have 340B status, we noted in the CY 2025 PFS proposed rule (89 FR 61972) that CMS is no longer pursuing this policy at this time but may consider it in future rulemaking

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Reduced lipogenesis and increased lipolysis in white adipose tissue Research demonstrated that NNMT inhibition by 5-Amino-1MQ reversed diet-induced obesity in mice, with significant reductions in body weight and white adipose tissue mass without affecting food intake