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BMSC-exos also inhibit the activation of certain inflammatory mediators and the NLRP3 inflammasome to exert anti-inflammatory effects in NP cells, thereby preventing the occurrence of degenerative changes [49]

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In animal models, TB-500 increased re-epithelialization rates and accelerated wound closure compared to placebo controls.- Clinical trials with thymosin beta-4 analogues showed improved outcomes in patients with chronic pressure ulcers.- BPC-157 studies demonstrated higher collagen deposition, angiogenesis, and granulation tissue formation in injured tissue models

This results in the production of two or more distinct polypeptide chains from a single mRNA molecule, a process known as polycistronic expression

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