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This is consistent with other ICI studies in which skin toxicities have been shown to appear sooner than endocrine imAEs

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However, there was no evidence of further reduction of ROS generation with the addition of ascorbic acid (Supplementary Fig

HPLC Method 2 retention time = 6.50 and 6.60 min (diastereoisomeric mixture)

Mitchell KG, Negrao MV, Parra ER, Li J, Zhang J, Dejima H, Vaporciyan AA, Swisher SG, Weissferdt A, Antonoff MB , Cascone T, Roarty E, Wistuba II, Heymach JV, Gibbons DL, Zhang J, Sepesi B

To address the limited evidence on sulfonation activity from clinical research, we developed a clinical metabolic phenotyping method using paracetamol as a probe substrate