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PMC 1874596

doi:10.1080/10409238.2017.1304353

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Although a recent trial has shown to be beneficial when antiviral treatment is introduced early during the disease before hospitalization than later in the course of the disease, there is an urgent need for early therapies to reduce the risk of disease progression, prevent transmission, and be widely distributed to meet the worldwide demand (Gottlieb et al., 2022

The association of Fe 2+ with lipoxygenases (LOX, a dioxygenase containing non-heme iron) can lead to oxygenation of polyunsaturated-fatty-acids (PUFA), such as arachidonic acid present in phospholipids, and trigger lipid peroxidation-induced ferroptosis (Kagan et al., 2017)