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Further investigation revealed hesperetin's ability to decrease expression of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL), two critical mediators of necroptosis pathways, suggesting its capacity to ameliorate DSS-induced intestinal inflammation through suppression of the RIPK3/MLKL necroptosis signaling cascade (67)

Besides, clinical outcomes have often been less robust than preclinical data suggested, partly due to the complexity of AMLs genetic and epigenetic heterogeneity, the limitations of model systems, and intrinsic resistance mechanisms

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And we've seen it in our hospital that very young children can get very sick

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