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IAV infection increases the levels of xanthine oxidase, which is an enzyme responsible for oxygen-free radical generation in mouse serum and lung tissues, thus promoting disease pathogenesis 73
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This metabolic perturbation significantly downregulates the expression of intestinal tight junction proteins, particularly ZO-1 (Mishra et al., 2023), thereby initiating a multistep pathogenic cascade: (i) compromised intestinal barrier integrity promotes bacterial translocation and systemic dissemination of deleterious metabolites
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BorborMYinDBrockmeierUWangCDoeckelMPillath-EilersMet al
