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Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-gamma and IL-12

Notably, neither cyclosporin A nor L-carnitine could rescue the membrane depolarization induced by the proton uncoupler FCCP (not shown)

These divergent findings emphasize the need to acknowledge uncertainty, consider biases, and integrate multi-level evidence from mechanistic experiments to population studies when evaluating carcinogen risk

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MP: Writing review & editing, Methodology

Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity